mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV

Abstract Background The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV remains obscure. In this study, we assessed the role of mTORC1 and mTORC2...

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Principais autores:	Jin Young Yang, Sanjar Batirovich Madrakhimov, Dong Hyuck Ahn, Hun Soo Chang, Sang Joon Jung, Seung Kwan Nah, Ha Yan Park, Tae Kwann Park
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2019-06-01
Serija:	Cell Communication and Signaling
Teme:	Age-related macular degeneration Choroidal neovascularization Sirolimus (rapamycin) mTORC1 mTORC2
Online dostop:	http://link.springer.com/article/10.1186/s12964-019-0380-0
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