Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis

Abstract Background Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fibrosis. Method Lrat:Cas9-ERT2:sgTif1γ mice were trea...

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Hlavní autoři:	Injoo Hwang, Eun Ju Lee, Hyomin Park, Dodam Moon, Hyo-Soo Kim
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2021-01-01
Edice:	Cell & Bioscience
Témata:	Retinol Hepatocytes Stimulated by retinoic acid 6 (STRA6) Lipogenesis Liver fibrosis
On-line přístup:	https://doi.org/10.1186/s13578-020-00509-w
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