Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

<p>Abstract</p> <p>Background</p> <p>Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. It is caused by mutations/deletions of the survival motor neuron 1 (<it>SMN1</it>) gene and is typified by the loss of spinal cord motor neurons, muscular atrophy, and in severe cases, de...

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Главные авторы:	Bowerman Melissa, Murray Lyndsay M, Boyer Justin G, Anderson Carrie L, Kothary Rashmi
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2012-03-01
Серии:	BMC Medicine
Предметы:	spinal muscular atrophy fasudil survival motor neuron protein NMJ muscle
Online-ссылка:	http://www.biomedcentral.com/1741-7015/10/24
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