Exercise, disease state and sex influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1 G93A amyotrophic lateral sclerosis (ALS) mouse model

Abstract Background Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease. Accumulating evidence strongly suggests that intrinsic muscle defects exist and contribute to disease progression, including imbalances in whole-body metabolic homeostasis. We have previ...

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Principais autores:	Gareth Hazell, Eve McCallion, Nina Ahlskog, Emma R. Sutton, Magnus Okoh, Emad I. H. Shaqoura, Joseph M. Hoolachan, Taylor Scaife, Sara Iqbal, Amarjit Bhomra, Anna J. Kordala, Frederique Scamps, Cedric Raoul, Matthew J. A. Wood, Melissa Bowerman
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2024-10-01
סדרה:	Skeletal Muscle
נושאים:	Amyotrophic lateral sclerosis Skeletal muscle TWEAK Fn14 Exercise Sex
גישה מקוונת:	https://doi.org/10.1186/s13395-024-00356-0
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