Ex vivo model of functioning human lymph node reveals role for innate lymphocytes and stroma in response to vaccine adjuvant

Summary: Immunological processes that underpin human immune responses to therapeutics and vaccine components, such as vaccine adjuvants, remain poorly defined due to a paucity of models that faithfully recapitulate immune activation in lymphoid tissues. We describe precision-cut human lymph node (LN...

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Detalhes bibliográficos

Principais autores:	Joannah R. Fergusson, Jacqueline H.Y. Siu, Nitya Gupta, Edward Jenkins, Eloise Nee, Sören Reinke, Tamara Ströbel, Ananya Bhalla, Shyami M. Kandage, Thomas Courant, Sarah Hill, Moustafa Attar, Michael L. Dustin, Alex Gordon-Weeks, Mark Coles, Calliope A. Dendrou, Anita Milicic
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-07-01
coleção:	Cell Reports
Assuntos:	CP: Immunology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124725007090
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