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Innate immune cell activation by adjuvant AS01 in human lymph node explants is age independent

Vaccine adjuvants are thought to work by stimulating innate immunity in the draining lymph node (LN), although this has not been proven in humans. To bridge the data obtained in animals to humans, we have developed an in situ human LN explant model to investigate how adjuvants initiate immunity. Sli...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Vicki V. Stylianou, Kirstie M. Bertram, Van Anh Vo, Elizabeth B. Dunn, Heeva Baharlou, Darcii J. Terre, James Elhindi, Elisabeth Elder, James French, Farid Meybodi, Stéphane T. Temmerman, Arnaud M. Didierlaurent, Margherita Coccia, Kerrie J. Sandgren, Anthony L. Cunningham
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2024-11-01
Schriftenreihe:The Journal of Clinical Investigation
Schlagworte:
Immunology
Vaccines
Online-Zugang:https://doi.org/10.1172/JCI174144
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