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The Bacterial Genomic Context of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases Highlights an Emerging Threat to Public Health

Type B dihydrofolate reductase (<i>dfrb</i>) genes were identified following the introduction of trimethoprim in the 1960s. Although they intrinsically confer resistance to trimethoprim (TMP) that is orders of magnitude greater than through other mechanisms, the distribution and prevalence of these...

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Principais autores: Claudèle Lemay-St-Denis, Sarah-Slim Diwan, Joelle N. Pelletier
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-04-01
Serier:Antibiotics
Fag:
antibiotic resistance
resistome
type II dihydrofolate reductase
genomic context
mobile genetic elements
Online adgang:https://www.mdpi.com/2079-6382/10/4/433
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