The Bacterial Genomic Context of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases Highlights an Emerging Threat to Public Health

Type B dihydrofolate reductase (<i>dfrb</i>) genes were identified following the introduction of trimethoprim in the 1960s. Although they intrinsically confer resistance to trimethoprim (TMP) that is orders of magnitude greater than through other mechanisms, the distribution and prevalence of these...

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Bibliographic Details

Main Authors:	Claudèle Lemay-St-Denis, Sarah-Slim Diwan, Joelle N. Pelletier
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2021-04-01
Series:	Antibiotics
Subjects:	antibiotic resistance resistome type II dihydrofolate reductase genomic context mobile genetic elements
Online Access:	https://www.mdpi.com/2079-6382/10/4/433
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