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The Bacterial Genomic Context of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases Highlights an Emerging Threat to Public Health

Type B dihydrofolate reductase (<i>dfrb</i>) genes were identified following the introduction of trimethoprim in the 1960s. Although they intrinsically confer resistance to trimethoprim (TMP) that is orders of magnitude greater than through other mechanisms, the distribution and prevalence of these...

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Autori principali: Claudèle Lemay-St-Denis, Sarah-Slim Diwan, Joelle N. Pelletier
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2021-04-01
Serie:Antibiotics
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Accesso online:https://www.mdpi.com/2079-6382/10/4/433
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