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Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4'-Fluorouridine.

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that has re-emerged to cause large outbreaks of human infections worldwide. There are currently no approved antivirals for treatment of CHIKV infection. Recently, we reported that the ribonucleoside analog 4'-fluorouridine (4'-FlU) is a highly...

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Principais autores: Peiqi Yin, Elizabeth B Sobolik, Nicholas A May, Sainan Wang, Atef Fayed, Dariia Vyshenska, Adam M Drobish, M Guston Parks, Laura Sandra Lello, Andres Merits, Thomas E Morrison, Alexander L Greninger, Margaret Kielian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2025-01-01
Serier:PLoS Pathogens
Online adgang:https://doi.org/10.1371/journal.ppat.1012859
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