Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4'-Fluorouridine.

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that has re-emerged to cause large outbreaks of human infections worldwide. There are currently no approved antivirals for treatment of CHIKV infection. Recently, we reported that the ribonucleoside analog 4'-fluorouridine (4'-FlU) is a highly...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Peiqi Yin, Elizabeth B Sobolik, Nicholas A May, Sainan Wang, Atef Fayed, Dariia Vyshenska, Adam M Drobish, M Guston Parks, Laura Sandra Lello, Andres Merits, Thomas E Morrison, Alexander L Greninger, Margaret Kielian
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Public Library of Science (PLoS) 2025-01-01
سلاسل:	PLoS Pathogens
الوصول للمادة أونلاين:	https://doi.org/10.1371/journal.ppat.1012859
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!