Circulating Follistatin-like 1 associates with inflammation, cognitive decline, and amyloid pathology in Alzheimer’s disease and promotes Aβ-induced neuronal ferroptosis via PI3K/Akt signaling

Abstract Background Alzheimer’s disease (AD) is characterized by progressive cognitive decline, neuroinflammation, and neuronal loss. However, the molecular factors linking amyloid pathology to regulated neuronal death and clinically accessible biomarkers remain incompletely understood. Follistatin-...

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Автори:	Min Hua, Wen-Ya Chen, Ai-Jin Ma, Man-Yun Cheng, Jie Meng, Lun-Lin Mao
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2026-03-01
Серія:	European Journal of Medical Research
Предмети:	Alzheimer’s disease Follistatin-like 1 Neuroinflammation PI3K/Akt signaling pathway Cognitive decline Ferroptosis
Онлайн доступ:	https://doi.org/10.1186/s40001-026-04341-9
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