Circulating Follistatin-like 1 associates with inflammation, cognitive decline, and amyloid pathology in Alzheimer’s disease and promotes Aβ-induced neuronal ferroptosis via PI3K/Akt signaling

Abstract Background Alzheimer’s disease (AD) is characterized by progressive cognitive decline, neuroinflammation, and neuronal loss. However, the molecular factors linking amyloid pathology to regulated neuronal death and clinically accessible biomarkers remain incompletely understood. Follistatin-...

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Główni autorzy:	Min Hua, Wen-Ya Chen, Ai-Jin Ma, Man-Yun Cheng, Jie Meng, Lun-Lin Mao
Format:	Artigo
Język:	Inglês
Wydane:	BMC 2026-03-01
Seria:	European Journal of Medical Research
Hasła przedmiotowe:	Alzheimer’s disease Follistatin-like 1 Neuroinflammation PI3K/Akt signaling pathway Cognitive decline Ferroptosis
Dostęp online:	https://doi.org/10.1186/s40001-026-04341-9
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