Substrate cooperativity shapes competitive inhibitor responses in mycobacterial inosine 5′-monophosphate dehydrogenase
Inosine 5′-monophosphate dehydrogenase (IMPDH) is a promising antimicrobial target due to its central role in guanine nucleotide biosynthesis. Accurate and reliable kinetic measurements are essential for evaluating inhibitors. However, the enzyme’s complex reaction mechanism and substrate cooperativ...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis Group
2026-12-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Assuntos: | |
| Acceso en liña: | https://www.tandfonline.com/doi/10.1080/14756366.2025.2598479 |
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