Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP
Abstract Guanosine 5′-monophosphate reductase (GMPR) is a crucial enzyme in the purine salvage pathway that catalyses the NADPH-dependent conversion of GMP to IMP, thereby contributing to purine nucleotide homeostasis. Mycobacterium smegmatis GMPR (MsmGMPR) contains a regulatory cystathionine β-synt...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Portfolio
2026-04-01
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| Edice: | Nature Communications |
| On-line přístup: | https://doi.org/10.1038/s41467-026-71657-9 |
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