Substrate cooperativity shapes competitive inhibitor responses in mycobacterial inosine 5′-monophosphate dehydrogenase
Inosine 5′-monophosphate dehydrogenase (IMPDH) is a promising antimicrobial target due to its central role in guanine nucleotide biosynthesis. Accurate and reliable kinetic measurements are essential for evaluating inhibitors. However, the enzyme’s complex reaction mechanism and substrate cooperativ...
Kaydedildi:
| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Taylor & Francis Group
2026-12-01
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| Seri Bilgileri: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Konular: | |
| Online Erişim: | https://www.tandfonline.com/doi/10.1080/14756366.2025.2598479 |
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