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RhoGEF Ect2 supports RhoA activity at cell–cell junctions through desmoplakin

We describe a mechanism by which the desmosome component, desmoplakin, can recruit and control the activity of the contractile signaling regulator RhoA at cardiomyocyte and keratinocyte intercellular junctions, with implications for cardiocutaneous health and disease pathogenesis. Desmoplakin (DP) i...

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Bibliografische gegevens
Hoofdauteurs: Hoda Zarkoob, Chen Y Kam, Jennifer L Koetsier, Erin McCarthy, Avinash Jaiganesh, David P Kelsell, Farah Sheikh, Lisa M Godsel, Kathleen J Green
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Life Science Alliance LLC 2026-06-01
Reeks:Life Science Alliance
Online toegang:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202503454
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