Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding
Abstract There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings. We have observed that certain beta-lactamases tend to aggregate, which persists throughout their evolution under the selective pres...
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| Glavni autori: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Portfolio
2023-09-01
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| Serija: | Nature Communications |
| Online pristup: | https://doi.org/10.1038/s41467-023-41191-z |
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