Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response

cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2’-3’-cyclic AMP-GMP (cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating downstream TBK1-IRF-3 signaling to initiate the expression of type I interferons. Although cGAS has been considered a traditi...

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Κύριοι συγγραφείς:	Yuying Ma, Xiaohui Wang, Weisheng Luo, Ji Xiao, Xiaowei Song, Yifei Wang, Hanlin Shuai, Zhe Ren, Yiliang Wang
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2021-11-01
Σειρά:	Frontiers in Immunology
Θέματα:	cGAS RNA-binding activity RNA-binding protein phase-separated condensates innate antiviral response
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.741599/full
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