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The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus

Activation of the DNA-dependent innate immune pathway plays a pivotal role in the host defense against poxvirus. Cyclic GMP-AMP synthase (cGAS) is a key cytosolic DNA sensor that produces the cyclic dinucleotide cGMP-AMP (cGAMP) upon activation, which triggers stimulator of interferon genes (STING),...

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Principais autores: Wen-Yu Cheng, Xiao-Bing He, Huai-Jie Jia, Guo-Hua Chen, Qi-Wang Jin, Zhao-Lin Long, Zhi-Zhong Jing
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-06-01
Serier:Frontiers in Immunology
Fag:
innate immunity
cGas
Sting
type I interferon
ectromelia virus
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2018.01297/full
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