Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha.

Interferon alpha (IFNα) is used for the treatment of hepatitis B virus infection, and whilst efficacious, it is associated with multiple adverse events caused by systemic exposure to interferon. We therefore hypothesise that targeting IFN directly to the intended site of action in the liver would re...

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書誌詳細

主要な著者:	Daniel Rycroft, Jane Sosabowski, Edward Coulstock, Marie Davies, John Morrey, Sarah Friel, Fiona Kelly, Robert Hamatake, Milan Ovečka, Rob Prince, Laura Goodall, Armin Sepp, Adam Walker
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2015-01-01
シリーズ:	PLoS ONE
オンライン･アクセス:	http://europepmc.org/articles/PMC4331089?pdf=render
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