Effect of Dosing Schedule on Pharmacokinetics of Alpha Interferon and Anti-Alpha Interferon Neutralizing Antibody in Mice

The influences of dosing time and dosing schedule on the plasma alpha interferon (IFN-α) concentration and the production of anti-IFN-α neutralizing antibodies were investigated in ICR male mice adapted to cycles of 12 h of light and 12 h of dark. In mice pretreated with IFN-α for 21 days, the plasm...

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Main Authors: Wang, De-sheng, Ohdo, Shigehiro, Koyanagi, Satoru, Takane, Hiroshi, Aramaki, Hironori, Yukawa, Eiji, Higuchi, Shun
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2001
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC90257/
https://ncbi.nlm.nih.gov/pubmed/11120962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.1.176-180.2001
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