Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha.

Interferon alpha (IFNα) is used for the treatment of hepatitis B virus infection, and whilst efficacious, it is associated with multiple adverse events caused by systemic exposure to interferon. We therefore hypothesise that targeting IFN directly to the intended site of action in the liver would re...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Daniel Rycroft, Jane Sosabowski, Edward Coulstock, Marie Davies, John Morrey, Sarah Friel, Fiona Kelly, Robert Hamatake, Milan Ovečka, Rob Prince, Laura Goodall, Armin Sepp, Adam Walker
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2015-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC4331089?pdf=render
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!