m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma

Abstract Background N6-Methyladenosine (m6A) modification has been implicated in many biological processes. It is important for the regulation of messenger RNA (mRNA) stability, splicing, and translation. However, its role in cancer has not been studied in detail. Here we investigated the biological...

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Hauptverfasser:	Li Liu, Jing Wang, Guifeng Sun, Qiong Wu, Ji Ma, Xin Zhang, Nan Huang, Zhixuan Bian, Song Gu, Min Xu, Minzhi Yin, Fenyong Sun, Qiuhui Pan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2019-12-01
Schriftenreihe:	Molecular Cancer
Schlagworte:	RNA m6A methylation Wnt/β-catenin pathway CTNNB1 Hepatoblastoma METTL3
Online-Zugang:	https://doi.org/10.1186/s12943-019-1119-7
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