The N6‐methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma

Abstract Background Solute carrier family 7 member 11 (SLC7A11) is overexpressed in multiple human tumours and functions as a transporter importing cystine for glutathione biosynthesis. It promotes tumour development in part by suppressing ferroptosis, a newly identified form of cell death that play...

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Hlavní autoři:	Li Liu, Jiangtu He, Guifeng Sun, Nan Huang, Zhixuan Bian, Chang Xu, Yue Zhang, Zhongqi Cui, Wenqiang Xu, Fenyong Sun, Chengle Zhuang, Qiuhong Man, Song Gu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2022-05-01
Edice:	Clinical and Translational Medicine
Témata:	ferroptosis hepatoblastoma IGF2BP1 m6A methylation resistance SLC7A11
On-line přístup:	https://doi.org/10.1002/ctm2.778
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