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Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug targets because they can produce fewer on-target side effects, improved selectivity, and better biological specificity (e.g., biased signaling or probe dependence) than orthosteric drugs. An underappreciated source...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Keith M. Olson, John R. Traynor, Andrew Alt
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021-10-01
Schriftenreihe:Frontiers in Chemistry
Schlagworte:
G-protein coupled receptor
pepducin
peptidomimetic
biased signaling
allosteric modulators
drug discovery
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fchem.2021.671483/full
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