Development of allosteric modulators of GPCRs for treatment of CNS disorders

The discovery of allosteric modulators of G protein-coupled receptors (GPCRs) provides a promising new strategy with potential for developing novel treatments for a variety of central nervous system (CNS) disorders. Traditional drug discovery efforts targeting GPCRs have focused on developing ligand...

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Principais autores:	Hilary Highfield Nickols, P. Jeffrey Conn
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2014-01-01
Serija:	Neurobiology of Disease
Teme:	Allosteric modulator CNS Drug discovery GPCR Metabotropic glutamate receptor Muscarinic acetylcholine receptor
Online dostop:	http://www.sciencedirect.com/science/article/pii/S0969996113002593
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