Allosteric modulation in monomers and oligomers of a G protein-coupled receptor

The M2 muscarinic receptor is the prototypic model of allostery in GPCRs, yet the molecular and the supramolecular determinants of such effects are unknown. Monomers and oligomers of the M2 muscarinic receptor therefore have been compared to identify those allosteric properties that are gained in ol...

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Autors principals:	Rabindra V Shivnaraine, Brendan Kelly, Krishana S Sankar, Dar'ya S Redka, Yi Rang Han, Fei Huang, Gwendolynne Elmslie, Daniel Pinto, Yuchong Li, Jonathan V Rocheleau, Claudiu C Gradinaru, John Ellis, James W Wells
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2016-05-01
Col·lecció:	eLife
Matèries:	GPCR allosteric modulation molecular dynamics muscarinic FRET oligomer
Accés en línia:	https://elifesciences.org/articles/11685
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