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TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia

TAL1 is ectopically expressed in about 30% of T-cell acute lymphoblastic leukemia (T-ALL) due to chromosomal rearrangements leading to the STIL-TAL1 fusion genes or due to non-coding mutations leading to a de novo enhancer driving TAL1 expression. Analysis of sequence data from T-ALL cases demonstr...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Naomi Thielemans, Sofie Demeyer, Nicole Mentens, Olga Gielen, Sarah Provost, Jan Cools
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Ferrata Storti Foundation 2022-03-01
Rangatū:Haematologica
Urunga tuihono:https://haematologica.org/article/view/10588
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