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Heterocyclic modified paclitaxel prodrug nanoassemblies for stimuli-responsive delivery via lysosomal escape

Prodrug nanoassemblies offer an innovative approach to drug delivery, but their lysosomal entrapment often impairs drug release. Notably, tertiary amine structures can undergo protonation reactions, thereby facilitating lysosomal escape through the proton sponge effect. In this study, we developed t...

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Principais autores: Mingyang Han, Hezhen Xu, Jun Yuan, Wenxiao Li, Hao Zhang, Hongkai Fang, Zhiyu Kuang, Yuanhao Yu, Danping Wang, Zhenzhen Zhao, Cong Luo, Bingjun Sun, Jin Sun
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-03-01
Serier:Acta Pharmaceutica Sinica B
Fag:
Heterocyclic tertiary amine
Lysosomal escape
Proton sponge effect
Paclitaxel prodrug nanoassemblies
Modular design
Stimuli-responsive
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211383526000390
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