Heterocyclic modified paclitaxel prodrug nanoassemblies for stimuli-responsive delivery via lysosomal escape

Prodrug nanoassemblies offer an innovative approach to drug delivery, but their lysosomal entrapment often impairs drug release. Notably, tertiary amine structures can undergo protonation reactions, thereby facilitating lysosomal escape through the proton sponge effect. In this study, we developed t...

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Bibliografske podrobnosti

Principais autores:	Mingyang Han, Hezhen Xu, Jun Yuan, Wenxiao Li, Hao Zhang, Hongkai Fang, Zhiyu Kuang, Yuanhao Yu, Danping Wang, Zhenzhen Zhao, Cong Luo, Bingjun Sun, Jin Sun
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2026-03-01
Serija:	Acta Pharmaceutica Sinica B
Teme:	Heterocyclic tertiary amine Lysosomal escape Proton sponge effect Paclitaxel prodrug nanoassemblies Modular design Stimuli-responsive
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2211383526000390
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