Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy: Effectively balance efficacy and safety

The clinical utility of irinotecan is restricted by individual variability in carboxylesterase expression. Direct administration of its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN38), presents an appealing alternative due to its potent anti-tumor efficacy. However, the undesirable properti...

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Κύριοι συγγραφείς:	Qing Wang, Shiyi Zuo, Shufang Zheng, Cuiyun Liu, Yaqiao Li, Jiayu Guo, Danping Wang, Shuo Wang, Wenjing Wang, Bowen Zhang, Minglong Huang, Xianbao Shi, Jin Sun, Zhonggui He, Bingjun Sun
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Tsinghua University Press 2025-01-01
Σειρά:	Nano Research
Θέματα:	irinotecan sn38 prodrug nanoassemblies disulfide bonds branched aliphatic chains
Διαθέσιμο Online:	https://www.sciopen.com/article/10.26599/NR.2025.94907011
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