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Pathogenesis of Thalassemia Major-associated Osteoporosis: A Review with Insights from Clinical Experience

Due to increasing life expectancy in thalassemia major (TM), osteoporosis is emerging as a significant problem. Its aetiology is multifactorial, culminating in increased bone resorption and impaired remodelling. Hypogonadism and marrow expansion seem to play an important role, but iron overload, def...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Agostino Gaudio, Nancy Morabito, Antonino Catalano, Rosario Rapisarda, Anastasia Xourafa, Antonino Lasco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Pediatric Endocrinology and Diabetes Society 2019-06-01
Schriftenreihe:JCRPE
Schlagworte:
Osteoporosis
thalassemia major
hypogonadism
marrow expansion
bone turnover
Online-Zugang: http://www.jcrpe.org/archives/archive-detail/article-preview/pathogenesis-of-thalassemia-major-associated-osteo/19095
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