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Pathogenesis of Thalassemia Major-associated Osteoporosis: A Review with Insights from Clinical Experience

Due to increasing life expectancy in thalassemia major (TM), osteoporosis is emerging as a significant problem. Its aetiology is multifactorial, culminating in increased bone resorption and impaired remodelling. Hypogonadism and marrow expansion seem to play an important role, but iron overload, def...

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Hoofdauteurs: Agostino Gaudio, Nancy Morabito, Antonino Catalano, Rosario Rapisarda, Anastasia Xourafa, Antonino Lasco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Pediatric Endocrinology and Diabetes Society 2019-06-01
Reeks:JCRPE
Onderwerpen:
Osteoporosis
thalassemia major
hypogonadism
marrow expansion
bone turnover
Online toegang: http://www.jcrpe.org/archives/archive-detail/article-preview/pathogenesis-of-thalassemia-major-associated-osteo/19095
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