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pHLIP-fused PD-L1 engages avelumab to elicit NK cytotoxicity under acidic conditions

Natural killer (NK) cells represent key player in immune surveillance to eliminate transformed or malignant cells. One of mechanisms of action of NK cells is antibody-dependent cell-mediated cytotoxicity (ADCC) by recognizing tumor antigens on the surface of cancer cells. However, the heterogeneity...

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Principais autores: Junjuan Feng, Hang Zheng, Yuting Zhang, Haiyan Wu, Mianjing Wang, Ying Sun, Min Zhang, He Xiao, Chunxia Qiao, Jing Wang, Longlong Luo, Xinying Li, Jiannan Feng, Yanchun Shi, Yuanqiang Zheng, Yi Wang, Dongsheng Sheng, Guojiang Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-05-01
Colecção:Heliyon
Assuntos:
PD-L1
pHLIP
NK cell
Cytotoxicity
Acidic
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405844024065824
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