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Preparation, expression, and anti-cancer effects of the novel fusion protein rONC-T7-pHLIP

Abstract Onconase (ONC), a novel antitumor protein, exhibits significant cytotoxic effects on various tumor cells. Although recent advancements have been made in ONC-based molecularly targeted drugs, most are single-targeting proteins with limitations such as poor targeting precision and low efficie...

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Principais autores: Ganggang Yang, Shaokang Wang, Yuhan Wang, Haigang Zheng, Meng Du, Ze Wang, Zhuo Chen, Cuifang Chang, Guoying Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2025-09-01
Colecção:Applied Microbiology and Biotechnology
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Acesso em linha:https://doi.org/10.1007/s00253-025-13578-z
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