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Head-to-head comparison of [177Lu]Lu-FAP-2286 and [161Tb]Tb-FAP-2286 efficacy in a PDAC mouse model

Abstract Background Terbium-161 (Tb-161) emits internal conversion and Auger electrons, in addition to beta-minus radiation, which might be of added benefit for targeted radionuclide therapy (TRT) compared to Lutetium-177 (Lu-177). We extensively compared Lu-177 and Tb-161 for fibroblast activation...

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Wedi'i Gadw mewn:
Prif Awduron: Circe D. van der Heide, Carolline M. Ntihabose, Mark Konijnenberg, Hanyue Ma, Debra Stuurman, Corrina de Ridder, Yann Seimbille, Michail C. Doukas, Erik de Blois, Simone U. Dalm
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: SpringerOpen 2026-01-01
Cyfres:EJNMMI Research
Pynciau:
Fibroblast activation protein (FAP)
Cancer-associated fibroblast (CAF)
Targeted radionuclide therapy (TRT)
Pancreatic ductal adenocarcinoma (PDAC)
Terbium-161
Mynediad Ar-lein:https://doi.org/10.1186/s13550-026-01372-5
Tagiau: Ychwanegu Tag
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