Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL

Abstract For children and young adults with T-lineage acute lymphoblastic leukemia (T-ALL), event free survival following relapse is < 10%. We recently showed that rearrangements of the mixed lineage leukemia gene (KMT2A-R) are associated with induction failure and an inferior survival in T-ALL. Bec...

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Principais autores:	Huining Kang, Nitesh D. Sharma, Christian K. Nickl, Meenakshi Devidas, Mignon L. Loh, Stephen P. Hunger, Kimberly P. Dunsmore, Stuart S. Winter, Ksenia Matlawska-Wasowska
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2018-08-01
Series:	Biomarker Research
Assuntos:	Gene expression KMT2A MLLT10 Leukemia Microarray T-ALL
Acceso en liña:	http://link.springer.com/article/10.1186/s40364-018-0141-z
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