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Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL

Abstract For children and young adults with T-lineage acute lymphoblastic leukemia (T-ALL), event free survival following relapse is < 10%. We recently showed that rearrangements of the mixed lineage leukemia gene (KMT2A-R) are associated with induction failure and an inferior survival in T-ALL. Bec...

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Main Authors: Huining Kang, Nitesh D. Sharma, Christian K. Nickl, Meenakshi Devidas, Mignon L. Loh, Stephen P. Hunger, Kimberly P. Dunsmore, Stuart S. Winter, Ksenia Matlawska-Wasowska
Format: Artigo
Language:Inglês
Published: BMC 2018-08-01
Series:Biomarker Research
Subjects:
Gene expression
KMT2A
MLLT10
Leukemia
Microarray
T-ALL
Online Access:http://link.springer.com/article/10.1186/s40364-018-0141-z
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