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Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy

Abstract Background Alpha-synuclein (α-Syn) aggregation is the primary characteristic of synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Immunotherapy targeting α-Syn has shown promising results in animal models of the disease....

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Main Authors: Jacqui T. Nimmo, Ajay Verma, Jean-Cosme Dodart, Chang Yi Wang, Jimmy Savistchenko, Ronald Melki, Roxana O. Carare, James A. R. Nicoll
Format: Artigo
Language:Inglês
Published: BMC 2020-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Immunotherapy
Synucleinopathies
Pathology
Parkinson’s disease
Dementia with Lewy bodies
Multiple system atrophy
Online Access:https://doi.org/10.1186/s13195-020-00727-x
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