Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy

Synucleinopathies represent a group of neurodegenerative disorders which are characterized by intracellular accumulation of aggregated α-synuclein. α-synuclein misfolding and oligomer formation is considered a major pathogenic trigger in these disorders. Therefore, targeting α-synuclein species repr...

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Detalhes bibliográficos

Principais autores:	Martin Kallab, Marcos Herrera-Vaquero, Malin Johannesson, Fredrik Eriksson, Jessica Sigvardson, Werner Poewe, Gregor K. Wenning, Eva Nordström, Nadia Stefanova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-07-01
coleção:	Frontiers in Neuroscience
Assuntos:	immunotherapy α-synuclein autophagy animal model α-synuclein clearance
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fnins.2018.00452/full
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