Spontaneous Suppressors against Debilitating Transmembrane Mutants of <i>Ca</i>Mdr1 Disclose Novel Interdomain Communication via Signature Motifs of the Major Facilitator Superfamily

The Major Facilitator Superfamily (MFS) drug:H⁺ antiporter <i>Ca</i>Mdr1, from <i>Candida albicans</i>, is responsible for the efflux of structurally diverse antifungals. MFS members share a common fold of 12–14 transmembrane helices (TMHs) forming two N- and C-domains. Each domain is arr...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Suman Sharma, Atanu Banerjee, Alexis Moreno, Archana Kumari Redhu, Pierre Falson, Rajendra Prasad
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-05-01
Edice:	Journal of Fungi
Témata:	<i>Candida albicans</i> antifungal resistance MFS transporter <i>Ca</i>Mdr1 drug:H<sup>+</sup> antiporter 1 interdomain crosstalk
On-line přístup:	https://www.mdpi.com/2309-608X/8/5/538
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!