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Spontaneous Suppressors against Debilitating Transmembrane Mutants of <i>Ca</i>Mdr1 Disclose Novel Interdomain Communication via Signature Motifs of the Major Facilitator Superfamily

The Major Facilitator Superfamily (MFS) drug:H<sup>+</sup> antiporter <i>Ca</i>Mdr1, from <i>Candida albicans</i>, is responsible for the efflux of structurally diverse antifungals. MFS members share a common fold of 12–14 transmembrane helices (TMHs) forming two N- and C-domains. Each domain is arr...

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Principais autores: Suman Sharma, Atanu Banerjee, Alexis Moreno, Archana Kumari Redhu, Pierre Falson, Rajendra Prasad
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-05-01
Serier:Journal of Fungi
Fag:
<i>Candida albicans</i>
antifungal resistance
MFS transporter
<i>Ca</i>Mdr1
drug:H<sup>+</sup> antiporter 1
interdomain crosstalk
Online adgang:https://www.mdpi.com/2309-608X/8/5/538
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