Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells

Abstract Background Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation. B cells are believed to be important APCs in the pathogenesis of autoimmune diseases and express CD80/CD86 after acti...

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Autors principals:	Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen, Chuen-Miin Leu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2020-03-01
Col·lecció:	Arthritis Research & Therapy
Matèries:	CTLA-4 CD80 CD86 TNF-α IL-6 Rheumatoid arthritis
Accés en línia:	http://link.springer.com/article/10.1186/s13075-020-2138-x
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