Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV)

We analyzed the spike protein S1/S2 cleavage of selected strains of a prototype coronavirus, mouse hepatitis virus (MHV) by the cellular protease furin, in order to understand the structural requirements underlying the sequence selectivity of the scissile segment. The probability of cleavage of sele...

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Autori principali:	Annette Choi, Ekaterina D. Kots, Deanndria T. Singleton, Harel Weinstein, Gary R. Whittaker
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-02-01
Serie:	Virus Research
Soggetti:	furin mouse hepatitis virus coronavirus spike protein structural criteria for spike cleavage by furin
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0168170223002459
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