Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif
Abstract Background The key evolutionary step leading to the pandemic virus was the acquisition of the PRRA furin cleavage motif at the spike glycoprotein S1/S2 junction by a progenitor of SARS-CoV-2. Two of its features draw attention: (i) it is absent in other known lineage B beta-coronaviruses, i...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2023-11-01
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| Colecção: | BMC Genomic Data |
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| Acesso em linha: | https://doi.org/10.1186/s12863-023-01169-8 |
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