Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage

A multistep priming process involving furin and endosomal cathepsin B and L (CatB/L) has been described for the Orthoebolavirus zairense (EBOV) glycoprotein GP. Inhibition or knockdown of either furin or endosomal cathepsins, however, did not prevent virus multiplication in cell cultures. Moreover,...

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Autors principals:	Dorothea Bestle, Linda Bittel, Anke-Dorothee Werner, Lennart Kämper, Olga Dolnik, Verena Krähling, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-09-01
Col·lecció:	Virus Research
Matèries:	Ebola virus GP cleavage Furin Endosomal cathepsins TMPRSS2
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0168170224001230
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