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Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity

The three RH-RhoGEFs differ in their sensitivity of activation by G proteins. For p115-RhoGEF, a specific molecular interaction with Gα13 is responsible for faster kinetics and lower sensitivity.

Furkejuvvon:
Bibliográfalaš dieđut
Váldodahkkit: Fabian Redlin, Anna-Lena Krett, Moritz Bünemann
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2022-11-01
Ráidu:Communications Biology
Liŋkkat:https://doi.org/10.1038/s42003-022-04224-9
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