Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity
The three RH-RhoGEFs differ in their sensitivity of activation by G proteins. For p115-RhoGEF, a specific molecular interaction with Gα13 is responsible for faster kinetics and lower sensitivity.
Kaydedildi:
| Asıl Yazarlar: | , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Portfolio
2022-11-01
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| Seri Bilgileri: | Communications Biology |
| Online Erişim: | https://doi.org/10.1038/s42003-022-04224-9 |
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