An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro

A crucial issue for Treg-based immunotherapy is to maintain a bona fide Treg phenotype as well as suppressive function during and after ex vivo expansion. Several strategies have been applied to harness Treg lineage stability. For instance, CD28 superagonist stimulation in vitro, in the absence of C...

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Үндсэн зохиолчид:	Paulo C. M. Urbano, Hans J. P. M. Koenen, Irma Joosten, Xuehui He
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2018-03-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	regulatory T cells tumor necrosis factor receptor 2 TNFα rapamycin tumor necrosis factor receptor 2 agonist antibody Treg stability
Онлайн хандалт:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00573/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!